#4: Virus-host interaction: molecular mechanisms
Thursday, December 17, 7pm GMT
New discoveries on the immune system of bacteria
The talk will described recent discoveries on new mechanisms by which bacteria defend themselves against phages.
The regulation and activity of Class 1 CRISPR-Cas systems
Bacteria CRISPR-Cas systems provide immunity against bacteriophages and mobile genetic elements. Although some bacteria modulate CRISPR-Cas in response to population density and other factors, a lack of high-throughput methods to systematically reveal regulators has hampered efforts to understand when and how immune strategies are deployed. Here, I will discuss multiple regulatory networks controlling CRISPR-Cas immunity that we have discovered through our development and application of a robust genome-wide approach.
Molecular hijacking of Pseudomonas
The molecular hijacking of the bacterial cell is driven by a remarkable diversity of phage-encoded mechanisms that modify replication, transcription and (post)translational modifications within the cell. In future, these systems may be exploited for antibacterial design strategies and biotechnological applications.
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand
KU Leuven, Department of Biosystems, Laboratory of Gene Technology, Kasteelpark Arenberg 21 - box 2462, B-3001, Leuven, Belgium.
Chairs
Department of Biochemistry, University of Toronto, Toronto, Canada
Institute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, 52425 Jülich, Germany
